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1

Safety of vaccine adjuvants: Focus on autoimmunity

van der Laan, Jan Willem, Gould, Sarah, Tanir, Jennifer Y.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.63 MB

english, 2015

2

Is current risk assessment of non-genotoxic carcinogens protective?

Braakhuis, Hedwig M., Slob, Wout, Olthof, Evelyn D., Wolterink, Gerrit, Zwart, Edwin P., Gremmer, Eric R., Rorije, Emiel, van Benthem, Jan, Woutersen, Ruud, van der Laan, Jan Willem, Luijten, Mirjam

Journal:

Critical Reviews in Toxicology

Year:

2018

Language:

english

File:

PDF, 1.29 MB

english, 2018

3

An interspecies comparison of placental antibody transfer: New insights into developmental toxicity testing of monoclonal antibodies

Nele Pentšuk, Jan Willem van der Laan

Journal:

Birth Defects Research Part B: Developmental and Reproductive Toxicology

Year:

2009

Language:

english

File:

PDF, 214 KB

english, 2009

4

Assessing immunotoxicity: guidelines

Jan Willem van der Laan, Henk van Loveren

Journal:

Fundamental & Clinical Pharmacology

Year:

2005

Language:

english

File:

PDF, 49 KB

english, 2005

5

Animal models in influenza vaccine testing

van der Laan, Jan Willem, Herberts, Carla, Lambkin-Williams, Robert, Boyers, Alison, Mann, Alexander J, Oxford, John

Journal:

Expert Review of Vaccines

Year:

2008

Language:

english

File:

PDF, 232 KB

english, 2008

6

Adjuvants enhancing an integral immune response to antigens

van der Laan, Jan Willem

Journal:

Expert Review of Vaccines

Year:

2005

Language:

english

File:

PDF, 67 KB

english, 2005

7

Current status and opportunities for therapeutic drug monitoring in the treatment of tuberculosis

Zuur, Marlanka A., Bolhuis, Mathieu S., Anthony, Richard, den Hertog, Alice, van der Laan, Tridia, Wilffert, B., de Lange, Wiel, van Soolingen, Dick, Alffenaar, Jan-Willem C.

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2016

Language:

english

File:

PDF, 841 KB

english, 2016

8

Quality of Life and Mortality after Endovascular, Surgical, or Conservative Treatment of Elderly Patients Suffering from Critical Limb Ischemia

Steunenberg, Stijn L., de Vries, Jolanda, Raats, Jelle W., Thijsse, Willem J., Verbogt, Nathalie, Lodder, Paul, van Eijck, Geert-Jan, Veen, Eelco J., de Groot, Hans G.W., Ho, Gwan H., van der Laan, Li

Journal:

Annals of Vascular Surgery

Year:

2018

Language:

english

File:

PDF, 436 KB

english, 2018

9

Shared Learnings on the New EMA First-in-Human and Early Clinical Trial Guideline: Proceedings From a DIAlogue Session at DIA Europe 2018

van der Laan, Jan Willem, Benson, Charles T., Janssens, Walter, Bos, Jeroen, Stahl, Elke, Brady, Joseph T., WÃ¤ndel-Liminga, Ulla, Corriol-Rohou, Solange, Forster, Roy, Hartmann, Andreas, Pertel, Pete

Journal:

Therapeutic Innovation & Regulatory Science

Year:

2020

Language:

english

File:

PDF, 248 KB

english, 2020

10

Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals

Heusinkveld, Harm, Braakhuis, Hedwig, Gommans, Robin, Botham, Phil, Corvaro, Marco, van der Laan, Jan Willem, Lewis, Dick, Madia, Federica, Manou, Irene, Schorsch, FrÃ©dÃ©ric, Wolterink, Gerrit, Woute

Journal:

Critical Reviews in Toxicology

Year:

2020

File:

PDF, 3.09 MB

2020

11

Therapy evaluation of laryngeal carcinomas by tyrosine-pet

Jurjan R. de Boer, Jan Pruim, Fred Burlage, Allard Krikke, Anton T. M. G. Tiebosch, Frans W. J. Albers, Willem Vaalburg, Bernard F. A. M. van der Laan

Journal:

Year:

2003

Language:

english

File:

PDF, 132 KB

english, 2003

12

Carbon-11 tyrosine PET for visualization and protein synthesis rate assessment of laryngeal and hypopharyngeal carcinomas

Jurjan R. de Boer, Bernard F. van der Laan, Jan Pruim, Tjin H. Que, Fred Burlage, Allard Krikke, Antoon T. Willemsen, Anton T. Tiebosch, Frans W. Albers, Willem Vaalburg

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2002

Language:

english

File:

PDF, 54 KB

english, 2002

13

Functional analysis of CD4+ CD25bright T cells in kidney transplant patients: improving suppression of donor-directed responses after transplantation

Varsha D.K.D. Sewgobind, Luc J.W. Van Der Laan, Mariska Klepper, Jan N.M. IJzermans, Huug W. Tilanus, Willem Weimar, Carla C. Baan

Journal:

Clinical Transplantation

Year:

2008

Language:

english

File:

PDF, 227 KB

english, 2008

14

Detection of unknown primary tumours and distant metastases in patients with cervical metastases: value of FDG-PET versus conventional modalities

Regelink, Gerreke, Brouwer, Jolijn, de Bree, Remco, Pruim, Jan, van der Laan, Bernard, Vaalburg, Willem, Hoekstra, Otto, Comans, Emile, Vissink, Arjan, Leemans, Ren&#x000E9,

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2002

Language:

english

File:

PDF, 58 KB

english, 2002

15

Dopaminertic and α1-adrenergic properties of B-HT920 revealed in morphine-dependent rats

Jan Willem Van der Laan

Journal:

Pharmacology Biochemistry and Behavior

Year:

1987

Language:

english

File:

PDF, 450 KB

english, 1987

16

Effect of chronic prenatal morphine treatment on μ-opioid receptor-regulated adenylate cyclase activity and neurotransmitter release in rat brain slices

Taco J. De Vries, Bernard J. Van Vliet, François Hogenboom, George Wardeh, Jan Willem Van der Laan, Arie H. Mulder, Anton N.M. Schoffelmeer

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1991

Language:

english

File:

PDF, 763 KB

english, 1991

17

S21: European view of preventing chronic risk from biologics

Jan Willem van der Laan

Journal:

Experimental and Toxicologic Pathology

Year:

2009

Language:

english

File:

PDF, 48 KB

english, 2009

18

Current status and burning issues in immunotoxicity testing of drugs

Jan Willem van der Laan, Henk van Loveren

Journal:

Toxicology and Applied Pharmacology

Year:

2005

Language:

english

File:

PDF, 104 KB

english, 2005

19

The RETHINK project: Minipigs as models for the toxicity testing of new medicines and chemicals: an impact assessment

Roy Forster, Gerd Bode, Lars Ellegaard, Jan Willem van der Laan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 149 KB

english, 2010

20

Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products

Jan Willem van der Laan, John Brightwell, Peter McAnulty, Joszef Ratky, Claudia Stark

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 293 KB

english, 2010

21

The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations

Roy Forster, Gerd Bode, Lars Ellegaard, Jan-Willem van der Laan

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2010

Language:

english

File:

PDF, 214 KB

english, 2010

22

Testing strategies for embryo-fetal toxicity of human pharmaceuticals. Animal models vs. in vitro approaches: A workshop report

Jan Willem van der Laan, Robert E. Chapin, Bert Haenen, Abigail C. Jacobs, Aldert Piersma

Journal:

Regulatory Toxicology and Pharmacology

Year:

2012

Language:

english

File:

PDF, 255 KB

english, 2012

23

O XIX C.1 - O XIX C.1 Moving away from a two species requirement for carcinogenicity studies: A regulatory perspective

Jan Willem van der Laan, Eric de Waal

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1997

Language:

english

File:

PDF, 128 KB

english, 1997

24

Mechanisms of Nongenotoxic Carcinogenesis and Assessment of the Human Hazard

Beatriz Silva Lima, Jan Willem Van der Laan

Journal:

Regulatory Toxicology and Pharmacology

Year:

2000

Language:

english

File:

PDF, 88 KB

english, 2000

25

The in Vivo Rodent Test Systems for Assessment of Carcinogenic Potential

Jan-Willem van der Laan, Per Spindler

Journal:

Regulatory Toxicology and Pharmacology

Year:

2002

Language:

english

File:

PDF, 74 KB

english, 2002

26

Testing Therapeutic Potency of Anticancer Drugs in Animal Studies: A Commentary

Willem Den Otter, Peter A. Steerenberg, Jan Willem Van der Laan

Journal:

Regulatory Toxicology and Pharmacology

Year:

2002

Language:

english

File:

PDF, 95 KB

english, 2002

27

Release of outer membrane fragments from normally growing Escherichia coli

Dick Hoekstra, Jan Willem van der Laan, Loe de Leij, Bernard Witholt

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1976

Language:

english

File:

PDF, 775 KB

english, 1976

28

Effects of inhibitors of GABA-transaminase on hole-board exploration and on temperature: Relation with effects on quasi-morphine abstinence behaviour induced by sodium dipropylacetate

Jan Willem van der Laan, Gradus Weick, Grada van Bleek

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 664 KB

english, 1985

29

The effects of centrally acting adrenergic agonists on temperature and on explorative and motor behaviour. Relation with effects on quasi-morphine withdrawal behaviour

Jan W. Van Der Laan, Willem Van Veenendaal, Paul Voorthuis, Gradus Weick, Feddo C. Hillen

Journal:

European Journal of Pharmacology

Year:

1985

Language:

english

File:

PDF, 451 KB

english, 1985

30

Dipropylacetate-induced shaking behaviour in the rat: a role of spinal α2-adrenoceptors

Jan Willem Van der Laan, Ris Dirksen

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 665 KB

english, 1988

31

In vitro cytokine release assays for predicting cytokine release syndrome: The current state-of-the-science. Report of a European Medicines Agency Workshop

Jean-Marc Vidal, Thomas T. Kawabata, Robin Thorpe, Beatriz Silva-Lima, Karin Cederbrant, Stephen Poole, Jan Mueller-Berghaus, Marc Pallardy, Jan-Willem Van der Laan

Journal:

Year:

2010

Language:

english

File:

PDF, 147 KB

english, 2010

32

WHO informal consultation on scientific basis for regulatory evaluation of candidate human vaccines from plants, Geneva, Switzerland, 24–25 January 2005

Jan Willem van der Laan, Philip Minor, Richard Mahoney, Charles Arntzen, Jinho Shin, David Wood

Journal:

Year:

2006

Language:

english

File:

PDF, 116 KB

english, 2006

33

The effect of pertussis toxin and whole-cell pertussis vaccine on haemodynamics and autonomic responsiveness in the rat depends on route of administration and age

Jan G.C. van Amsterdam, Jan-Dirk te Biesebeek, Ton van de Kuil, Jan-Willem van der Laan, Johan Wemer, Dick J. de Wildt, Wim Vleeming

Journal:

Year:

1998

Language:

english

File:

PDF, 768 KB

english, 1998

34

Repeated administration of whole-cell and acellular pertussis vaccines affects haemodynamics and autonomic responsiveness

Jan G.C. van Amsterdam, Jan-Dirk te Biesebeek, Ton van de Kuil, Jan-Willem van der Laan, Dick J. de Wildt, Wim Vleeming

Journal:

Year:

1998

Language:

english

File:

PDF, 872 KB

english, 1998

35

Chronic exposure to morphine and naltrexone induces changes in catecholaminergic neurotransmission in rat brain without altering μ-opioid receptor sensitivity

Taco J. De Vries, Guno H.K. Tjon Tien Ril, Jan Willem Van der Laan, Arie H. Mulder, Anton N.M. Schoffelmeer

Journal:

Year:

1993

Language:

english

File:

PDF, 612 KB

english, 1993

36

Oseltamivir and breastfeeding

Netteke Wentges-van Holthe, Marion van Eijkeren, Jan Willem van der Laan

Journal:

International Journal of Infectious Diseases

Year:

2008

Language:

english

File:

PDF, 90 KB

english, 2008

37

Testing strategies for assessment of carcinogenic risk of drugs: Current developments

Jan Willem Van der Laan

Journal:

Toxicology Letters

Year:

2007

Language:

english

File:

PDF, 72 KB

english, 2007

38

Regulatory view on the relevance of the TDAR in immunotoxicity testing

Jan-Willem van der Laan

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 54 KB

english, 2009

39

New perspectives for alternative approaches to carcinogenicity testing: a regulator viewpoint

Jan Willem van der Laan

Journal:

Toxicology Letters

Year:

1998

Language:

english

File:

PDF, 63 KB

english, 1998

40

W8/L3 - New perspectives for alternative approaches to carcinogenicity testing: A regulator viewpoint

Jan Willem van der Laan

Journal:

Toxicology Letters

Year:

1998

Language:

english

File:

PDF, 242 KB

english, 1998

41

Current status and use of short/medium-term models for assessment of carcinogenicity of human pharmaceuticals: regulatory perspectives

Jan Willem van der Laan

Journal:

Toxicology Letters

Year:

2000

Language:

english

File:

PDF, 67 KB

english, 2000

42

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || Toxicokinetics: A Guidance for Assessing Systemic Exposure in Toxicology Studies, Where Are We Now; An S3A/S3B Update (1995–2011)

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 582 KB

english, 2013

43

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || The Value and Benefits of the International Conference on Harmonisation (ICH) to Drug Regulatory Authorities: Advancing Harmonization for Better Public Health

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 109 KB

english, 2013

44

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || EU Perspective on ICH

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 200 KB

english, 2013

45

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || The International Conference on Harmonisation: History of Safety Guidelines

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 199 KB

english, 2013

46

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || Toward More Scientific Relevance in Carcinogenicity Testing

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 344 KB

english, 2013

47

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || A Japanese Perspective on Implementation of the Three Rs: Incorporating Best Scientific Practices into Regulatory Process

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 305 KB

english, 2013

48

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || Why and How Did Reproduction Toxicity Testing Make Its Early Entry into and Rapid Success in ICH?

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 555 KB

english, 2013

49

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || Duration of Acute and Chronic Toxicity Testing in Animals (ICH S4A and S4B)

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 425 KB

english, 2013

50

[AAPS Advances in the Pharmaceutical Sciences Series] Global Approach in Safety Testing Volume 5 || The Evolution, Scientific Reasoning and Use of ICH S2 Guidelines for Genotoxicity Testing of Pharmaceuticals

van der Laan, Jan Willem, DeGeorge, Joseph J.

Year:

2013

Language:

english

File:

PDF, 564 KB

english, 2013

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